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KMID : 0858420120140010000
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Korean Journal of Stroke
2012 Volume.14 No. 1 p.0 ~ p.0
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Antiplatelet Therapy for Secondary Stroke Prevention: 2012 Focused Update of Korean Clinical Practice Guidelines for Stroke
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Park Tae-Hwan
Kim Min-Ky
Oh Hyung-Geun
Oh Mee-Sun
Yu Kyung-Ho
Hong Keun-Sik
Bae Hee-Joon
Kwon Sun-Uck
Rha Joung-Ho
Heo Ji-Hoe
Oh Chang-Wan
Lee Byung-Chul
Yoon Byung-Woo
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Abstract
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Writing Committee of Korean clinical practice guidelines for secondary prevention of stroke has reviewed recent randomized controlled trials of cilostazol published after the fi rst edition of Korean clinical practice guidelines that considered evidences published before June 2007. Two clinical trials and 1 meta-analysis which compared cilostazol directly with aspirin in the prevention of stroke in patients with cerebral infarction or transient ischemic attack (TIA) were identifi ed and included for the current guideline update. Review of fi ndings indicates that cilostazol as compared to aspirin achieved a greater reduction of stroke as well as composite vascular events of stroke, myocardial infarction, and vascular death. For safety, cilostazol was associated with fewer major bleeding events than aspirin. Accordingly, new recommendations for cilostazol are made for prevention of stroke in the setting of noncardioembolic stroke or TIA. Changes in the guidelines necessitated by new evidences will be continuously refl ected in future guidelines. (Korean J Stroke 2012;14:1-5)
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KEYWORD
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Practice guideline, Stroke, Secondary prevention, Cilostazol, Aspirin
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